Cerebellum has a significant role in motor control, cognitive functions as attention, language and regulating pleasure or fear responses. It does not initiate movement, it contributes to coordination, precision and accurate timing. It receives input from sensory systems of the spinal cord and from other regions of the brain and integrates them to fine tune motor activity. Patients suffered from cerebellar damage have disorders in fine movement, equilibrium, posture and motor learning . Estrogens guide cerebellar development. Cerebellum itself may be a source of estradiol through local steroid hormone synthesis as estradiol uptake was also observed in cerebellum. So, the cerebellum is considered as a target of estrogen action. The adult cerebellum expresses both estrogen receptor alpha (Erα) and Erβ . Erα expression in adults is localized primarily to granule cells, but at low concentrations. In contrast, the adult cerebellum expresses high levels of Erβ, primarily in Purkinje cells and also in cerebellar granule cells. In ovariectomized rats and postmenopausal women, hormone replacement therapy (HRT) with estrogen was applied to relieve vasomotor symptoms. It has also been reported that estrogen replacement therapy improves learning and memory function of the brain.