Reporting that nicotine is a major toxic component of cigarette smoke was done. Also, that the long half-life cotinine, which is the metabolite after nicotine oxidation, could play a significant role in vascular diseases. Authors reported that that chronic administration of nicotine to rats induces cytochrome P-450 together with generation of free radicals in tissues of rats and exerts oxidative tissue injury. Caffeine beverages connected to the family of alkaloids and the methylxanthine team . Caffeine beverages were normally can found in several vegetation, such as coffees, candy legumes and tea. Caffeine has a positive effect on the central neurological system, pulse amount, and breathing. It has feelings changing qualities, and also acts as a light diuretic . Caffeine beverages can found in variety of popular products such as tea, coffee, candy, sodas including pharmacological products as a psycho-stimulant