Diabetes mellitus (DM) is a potentially serious metabolic disorder with increasing occurrence all over the world. According to the International Diabetes Federation, there was approximately 366 million people suffered from DM (aged 20-79 years) in 2011 and this figure would climb up to 552 million by the year of 2030. All types of DM are characterized by hyperglycemia and the progression of multiple debilitating complications. In addition to infection and premature death, diabetic complications include cerebrovascular disorders, myocardial infarction, renal failure, blindness, limb amputation and a variety of neuropathies . The skeletal muscle is notably affected by DM. It has been discovered that DM induces skeletal muscle atrophy, fiber-type alteration from oxidative to glycolytic and impaired energy metabolism in skeletal muscle. These changes result in skeletal muscle dysfunction, such as muscle weakness and exercise intolerance. Moreover, the commonest cause of peripheral neuropathy is diabetes, and 30-90% of patients with diabetes have peripheral neuropathy. Diabetic peripheral neuropathy is characterized by pain, paraesthesia and sensory loss.