Renal Cell Carcinoma Associated with Xp11.2 Translocation/Transcription Factor E3 (TFE3) Fusion

Microscopically, Xp11.2 TRCCs show papillary and/or nested architecture in a background of prominent capillary vasculature . Areas with a solid growth pattern are rarely observed. The neoplastic cells are voluminous and polygonal, with clear and/or eosinophilic granular cytoplasm. The nuclei are vesicular with prominent nucleoli. The stroma is desmoplastic and contains a variable amount of lymphocytes. Psammomatous calcifications and foci of stromal eosinophilic hyaline globules may be numerous and widespread. Satellite tumor nodules, multifocal necrosis and lymphovascular invasion are frequently observed.