fection poses significant global health challenges. As it became a global epidemic sweeping all countries of the world which prompted scientists around the world to search for a quick or safe treatment to preserve people's lives. Pomegranates have been known for hundreds of years for their multiple health benefits, including antiviral activity. Many studies have utilized pomegranate peels with success [1-3]. There are many of phytochemical compounds in pomegranate that have demonstrated antimicrobial activity; on the other hand many studies have found that ellagic and larger hydrolysable tannins, such as punicalagin, have the excellent activities. Generally the combination of the pomegranate compounds offers the most benefit. Pomegranate antiviral effects have been reported against influenza virus, poxviruses, herpes virus, and human immunodeficiency (HIV-1) virus. A recent study attributed the curative effect of pomegranate on viruses due to the high phenolic content (44%) in the peels