In tumor cells two types of sialomucins have been observed. One type of sialomucin is released from the tumor cells whereas other is on the cell surface as a heterodimeric complex. Sialomucins protect tumor cells from the immune system due to their large size, extended structure and negative charge preventing immune and tumor cells interactions. Presence of sialomucin leads to decreased adhesion of tumor cells to the connective tissue, increasing tumor chances to metastatize Various studies done on sialomucins showed its presence in metaplastic and neoplastic epithelium, but not in normal gastric mucosa. A study by Mull revealed presence of O acetyl sialomucin in 42.9% cases of gastric adenocarcinoma. In a study conducted at China, the incidence of O acetyl sialomucin was higher in intestinal adenocarcinoma Mandal in 2013 illustrated the presence of sialomucins in intestinal type of gastric adenocarcinomas. In the light of the above-mentioned facts this study was designed to see the morphological types of gastric adenocarcinoma and amount of sialomucin in adenocarcinoma in gastric biopsies.

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