Columnar Cell Variant of Papillary Thyroid Carcinoma: Cytological and Histopathologic Correlation

Thyroid cancer is considered the most common endocrine malignancy, PTC is the commonest malignancy involving the thyroid gland and represents up to 80%. Thyroid carcinoma are classified into; differentiated thyroid carcinoma (DTC) that included papillary, follicular, Hürthle cell, and medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC), PTC is the most common type whereas, ATC is the least one. Histologically, there are many subtypes of PTC, one of them is PTC-CCV which is initially mentioned by Evansetalin 1986, it is a rare entity and accounts up to 0.4% of all PTC cases. PTC-CCV is characterized by some unique features as rapid growth rate, local invasion and early development of lymph node metastasis, and has a high rate of recurrence with bad response to radioactive iodine therapy.The latest WHO classification of endocrine neoplasm defined this variant as hypercellular neoplasm exhibiting thin papillae or glandular-like spaces lined by pseudostratified epithelium. The cells may show occasional subnuclear vacuolization or even clear cytoplasm. This article is focused on previously done FNAC of thyroid nodules and their received surgical specimens with correlation of the cytologic and Histological findings.