Chromosomal Distribution of Human Disease Genes

Inflammatory Bowel Disease (IBD) is one of the most common diseases of the gastrointestinal tract. Chronic inflammation of the intestine occurs in Ulcerative Colitis (UC) and Crohn's disease. In UC, inflammation is limited to the colon and rectum, whereas Crohn's disease affects the entire tract from the mouth to the anus, eventually damaging bowel function. IBD is most prevalent in Europe and the United States .The exact cause of these diseases has not yet been determined. However, various factors were suggested for the etiology of these diseases, including the role of environmental factors, genetic abnormalities, immune responses, and westernization of lifestyles such as diet change, smoking, and geographical location.