Ovarian carcinoma is the 5th most common cause of cancer related deaths in Western world and leading cause of death from gynecologic malignancy.The 5-year survival is only 30–40% and is due to the fact that most ovarian cancers are in operable when first discovered. There is no reliable means for early detection except for genetic screening in high risk individuals. The understanding of the molecular pathogenesis of ovarian cancer has been hindered by the lack of sufficient number of specimens at early-stage disease. As a result, identifiable precursor lesions that ultimately develop into ovarian cancer are still debatable. The etiology of ovarian cancers is poorly understood. Previous epidemiological studies have focused on etiology of epithelial tumors and found advanced age, nulliparity and a family history of ovarian cancer to be consistently associated with an increased risk while number of pregnancies, oral contraceptive use [6] and history of hysterectomy or tubal ligation has been found to be associated with a decreased risk.